Deucrava (Deucravacitinib), generic  SOTYKTU is a prescription medicine used to treat certain type of skin condition (moderate-to-severe plaque psoriasis) in patients who need systemic therapy or phototherapy. Deucravacitinib should not be used with other potent immunosuppressants. Deucravacitinibis a drug that blocks the activity of tyrosine kinase 2 (TYK2), an enzyme that is involved in inflammation and immune responses. Deucravacitinib binds to a part of TYK2 that regulates its function, and prevents it from being activated by certain receptors on the cell surface. This reduces the signaling of proteins called STATs, which are important for the development of psoriasis. TYK2 works with other enzymes called JAKs to form pairs that transmit signals from different cytokines, which are molecules that regulate inflammation and immunity. Deucravacitinib can inhibit the pairs of TYK2 and JAK1 or TYK2 and JAK2, as shown in cell-based studies.